Charlie and Itchy live in San Francisco as guardian angels. In each episode, they are given a mission by Anabelle but, while they try to do the right thing, they become caught up in the middle of difficult situations. Charlie’s villainous rival Carface and his sidekick, Killer (from the first film), also appeared in the series, as did Charlie’s friends: the dog Sasha, the dog-angel Anabelle, and the human kid David. Finally, the series also featured two new characters named Bess, a pure bred award winning show dog and Itchy's love interest, and Belladonna, Anabelle's demonic antagonist cousin. The series makes several changes to the second film. For example, Charlie and Sasha were shown as being together at the end of the second film, however, in the series, they seem to have never had a first date together; also, Itchy decides to stay in Heaven, but he is alive in the series, although it becomes clear later in the series why he is on Earth instead of being in Heaven.