Janus Lee, head of Lee Industries, holds a television contest as a front to recruit a group of talented teenagers. Using prototype weapons, gadgets and vehicles, the Alpha Teens, Axel, King, Hawk, Shark and Lioness join forces to battle against the criminal mastermind, Alexander Paine. However, after Paine's defeat, it is revealed that Lee's true purpose was to use the teens DNA to create clones powered with animal genes. The Alpha Teens once again have to team up to stop Lee and his army of mutants.