Set in the future on a partially terraformed Mars, teenager Tuesday Simmons runs away from her affluent lifestyle as the daughter of a politician and makes her way to Alba City to pursue her dream of being a musician with just a suitcase and her Gibson acoustic guitar. On her first day in the city, she crosses paths with Carole Stanley, another aspiring musician who plays the piano, and the two decide to team up as a singer-songwriter duo under the name Carole & Tuesday.