The series focuses on the daily life of Clarence Wendle, a fun-loving and spirited 10-year-old boy, and his best friends: Jeff, who is the more intellectual type, and Sumo, who often uses drastic measures when solving problems. Clarence lives with his divorced mother Mary and her boyfriend Chad in the fictional town of Aberdale. Each episode focuses on the daily-life situations and problems that Clarence and his friends encounter, and their everyday adventures and life experiences as kids. Other characters include students and faculty at Aberdale Elementary, Clarence's school. Certain episodes focus on the life of supporting characters, like the citizens of Aberdale and Clarence's classmates.