Ty and Abby are a teen brother and sister crime-fighting team who report to the Bureau of Grossology, a secret government facility whose job is to investigate gross criminals, their gross crimes, and/or various gross phenomena. Each episode of the series follows the pair on adventures based on real scientific facts. Aided by their friend Lab Rat (a human scientist), their boss The Director, and their police liaison, The Detective, Ty and Abby work to keep the city safe, all while keeping their identities hidden. (Oddly, villains never recognize Abby apart from her Grossology uniform, despite her floor-length ponytail.)