Bride-to-be Susan Murphy is struck by a meteorite on the day of her wedding to weather reporter Derek Dietl. Instead of killing her, the meteorite exposes her to the substance quantonium, causing her to rapidly grow to over 50 feet tall. Alerted to the meteorite, first by an Arctic base and then the priest at Susan's wedding, the military arrives and captures Susan. She is given the code name "Ginormica" and sent to a top-secret secure facility headed by General W.R. Monger. There she meets her fellow monster inmates: B.O.B. , a brainless, indestructible gelatinous blob; Dr. Cockroach, PhD, a mad scientist with the head and abilities of a cockroach; the Missing Link, an amphibious fish-ape hybrid; and Insectosaurus, a massive grub that is even larger than Susan...