Set in the 22nd century in New London, Inspector Beth Lestrade of New Scotland Yard is chasing the grotesquely deformed French rogue geneticist Martin Fenwick, when she realizes that his companion is none other than the 19th century criminal mastermind Professor James Moriarty. She then discovers that this is not the original Moriarty, but rather a clone created from cells taken from his corpse, which Sherlock Holmes had buried in a Swiss ice cave after Moriarty's death in 1891.