The main character in the show is Sid, an "inquisitive youngster" who uses comedy to tackle questions kids have about basic scientific principles and why things work the way they do. He tries to answer questions and solve problems with the help of his classmates (May, Gerald, and Gabriela), Teacher Susie, and his family (his mother Alice, his father Mort, his Grandma Rose and his baby brother Zeke). In "Hello Doggie," Sid's Grandma adopts a dog from the animal shelter. The conceptual content of Sid is based in national science learning standards, cognitive learning theory, and on the preschool science curriculum, Preschool Pathways to Science.