Space Ghost, along with teenaged sidekicks Jan and Jace and their pet monkey Blip, fight villains in outer space. Usually, Space Ghost's sidekicks would get captured or trapped by the villains, and Space Ghost would have to defeat the villains and save the day. His enemies included Zorak, Brak and his brother Sisto, the Creature King, the Black Widow (a.k.a. the Spider Woman), Lokar, Moltar, and Metallus.