Set shortly after the events of the 2002 film,[2] Peter Parker, and his friends Mary Jane Watson, and Harry Osborn start attending Empire State University together. Peter and Mary Jane try to establish a relationship without much success. Peter's superhero duties, and later his involvement with Indira Daimonji, interfere with his romance with Mary Jane, while Harry continuously blames Spider-Man for the death of his father Norman Osborn. Peter faces an assortment of other villains including the Lizard, Kraven the Hunter and Electro while trying to maintain a job and his studies. He faces two psychic twins that ruin everything in the wallcrawler's life, causing Peter to give up being Spider-Man and try to live a normal life.
