Spliced is a modern take of H. G. Wells' 1896 science-fiction fantasy, The Island of Doctor Moreau. Spliced marginally distorts Wells' characters in this modern twist by making the mutants the result of genetic experiments created by recombinant DNA rather than Wells' original vivisection process. As with the original story, these experimental results, plus one platypus not in the original story, live on an isolated tropical island that is called "Keep Away Island" in the cartoon. The mad scientist who created them was arrested and removed by authorities via boat. Left to their own devices, these mutated beasts form a functional society.