The League of Super Evil (or "L.O.S.E.") is a group of so-called "supervillains" who are plotting to take over their neighborhood in Metrotown and the world ultimately but their plans usually involve pranks such as gluing a penny to a chair. While all the other citizens in the neighborhood live in suburban houses, The League has a "secret evil lair". The League is often at odds with other, more important and competent super villains such as Skullossus and also tries to avoid getting busted by Metrotown's heroes.