Based on the classic children's book series Mr. Men and Little Miss, the show takes place in the fictional town of Dillydale in the mythical continent of Misterland. The show revolves around the characters from the books (though a few of the characters were made for the show) and their adventures in Dillydale. Unlike the books (which featured characters such as Mr. Tickle, Mr. Bump, Mr. Happy, Mr. Strong, Mr. Tall, Little Miss Bossy, Little Miss Sunshine, Little Miss Tiny, Little Miss Giggles, and Little Miss Chatterbox as major characters), the TV show features the more minor characters more prominently (such as Little Miss Curious, Mr. Grumpy, and Mr. Lazy). Most of the episodes are not based on the books but are, in fact, new stories. There are also several changes to the TV show.