YooHoo & Friends is about five executives who worked for Nasty Corporation. When Mother Nature notices that they've been slowly destroying the world, she pressures Father Time to stop them from polluting the Earth by turning them into five animals. Together, Lemmee the sourpuss, Roodee the inventor, Pammee the princess, optimistic Chewoo, and their leader YooHoo save the world from all of the environmental disasters they caused as their former human-selves, in return for the gemstones Father Time planted in the locations they visit. When all of the gems are found, the Furry 5 are able to make a wish to become human again. Each episode also includes a narration from Father Time as he goes back to certain times from the past and fixes them.