The Despicable Shinigami.Orihime and Uryū continue towards Rukia's location, but are accosted by Makizō Aramaki, a Soul Reaper of the eleventh division. Some twelfth division members arrive to help, but Mayuri, who has made them into human bombs, detonates them. Orihime uses her powers to protect Uryū and herself from the explosions, and Mayuri expresses his wish to experiment on Orihime. Uryū begins to fight Mayuri, but is quickly disabled by the paralyzing abilities of Mayuri's zanpakutō when his lieutenant, Nemu Kurotsuchi, uses her body to hold down Uryū. Mayuri then reveals that he has experimented on many other Quincy, including Uryū's grandfather, Sōken Ishida, and was responsible for his death.