Dream Yoichi Isagi is a football player on the Ichinan high school team. A second-year student, his position on the team is as a center forward and his dream is to become Japan's greatest ace in that position. Unfortunately, however, he loses in his decisive match for the national championship. However, he receives a mysterious invitation from the Japanese Football Union for something he didn't expect: to enter the Blue Lock, where he will live with 300 other forwards to compete for who will make the Japanese national team.