The Powerpuff Girls MovieProfessor Utonium creates a mixture of sugar, spice, and everything nice in hope of producing the perfect little girl to improve Townsville, a city plagued by crime and injustice. He is shoved by his laboratory assistant, the destructive chimpanzee Jojo, causing him to accidentally break a nearby flask of a mysterious substance called Chemical X, which spills into the mixture and explodes in Jojo's face. The experiment is successful, producing three little girls whom the Professor names Blossom, Bubbles, and Buttercup. He discovers that the girls also have superpowers from the added Chemical X. Despite the girls' recklessness with their powers, they all immediately grow to love each other as a family.During their first day of school, the girls learn about the game tag and begin to play among themselves, which quickly grows destructive once they use their powers. The girls take their game downtown, accidentally causing massive damage to the city until the Professor calms them down. The next day, the girls are treated as outcasts by the citizens of Townsville as a result of the destruction they have caused, and the Professor is arrested for creating the girls. Realizing that using their powers again will only anger the townspeople more, the girls try to make their way home from school on foot. They become lost in an alleyway and are ambushed by the Gangreen Gang, only to be rescued by Jojo, whose brain has been mutated by the Chemical X explosion, which gives him superintelligence...