Billed as "an exciting hybrid of high school drama and giant robot battles", Sym-Bionic Titan features "the adventures of three beings from the planet Galaluna who crash-land on Earth while attempting to escape their war-torn world." The series follows the lives of Ilana, Lance, and Octus, two alien teens and a robot in the form of humanoids who arrive on Earth, an "identical" planet to Galaluna, while fleeing an evil general who has taken over their home planet with the help of monstrous creatures called Mutraddi.